A mathematical model of immune activation with a unified self-nonself concept

A mathematical model of immune activation with a unified self-nonself concept

The adaptive immune system reacts against pathogenic nonself, whereas it normally remains tolerant to self. The initiation of an immune response requires a critical antigen(Ag)-stimulation and a critical number of Ag-specific T cells. Autoreactive T cells are not completely deleted by thymic selecti...

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Bibliographic Details
Main Authors:	Sahamoddin eKhailaie, Fariba eBahrami, Mahyar eJanahmadi, Pedro eMilanez-Almeida, Jochen eHuehn, Michael eMeyer-Hermann
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2013-12-01
Series:	Frontiers in Immunology
Subjects:	Autoimmunity Central Tolerance Peripheral Tolerance regulatory T cells Autoreactive T cells immune activation
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00474/full

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