The Anticancer Drug Bleomycin Shows Potent Antifungal Activity by Altering Phospholipid Biosynthesis

The Anticancer Drug Bleomycin Shows Potent Antifungal Activity by Altering Phospholipid Biosynthesis

ABSTRACT Invasive fungal infections are difficult to treat with limited drug options, mainly because fungi are eukaryotes and share many cellular mechanisms with the human host. Most current antifungal drugs are either fungistatic or highly toxic. Therefore, there is a critical need to identify impo...

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Bibliographic Details
Main Authors: Mona Pokharel, Paulina Konarzewska, Jacques Y. Roberge, Gil-Soo Han, Yina Wang, George M. Carman, Chaoyang Xue
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
Cryptococcus neoformans
phosphatidylserine synthase
PS synthase assay
inhibitor
bleomycin
mitochondria
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00862-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00862-22

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