Positive association between plasmatic levels of orexin A and the endocannabinoid-derived 2-arachidonoyl lysophosphatidic acid in Alzheimer’s disease

Positive association between plasmatic levels of orexin A and the endocannabinoid-derived 2-arachidonoyl lysophosphatidic acid in Alzheimer’s disease

A regular sleep-wake cycle plays a positive function that preserves synaptic plasticity and brain activity from neuropathological injuries. The hypothalamic neuropeptide orexin-A (OX-A) is central in sleep-wake regulation and has been found to be over-expressed in the cerebrospinal fluid (CSF) of pa...

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Bibliographic Details
Main Authors: Nicola Forte, Alba Clara Fernández-Rilo, Letizia Palomba, Brenda Marfella, Fabiana Piscitelli, Paolo De Girolamo, Alfonso Di Costanzo, Vincenzo Di Marzo, Luigia Cristino
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
hypocretin (orexin)
sleep
neurodegeneration
tau phosphorylation
serum biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.1004002/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.1004002/full

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