Direct evidence of CRISPR-Cas9-mediated mitochondrial genome editing

Direct evidence of CRISPR-Cas9-mediated mitochondrial genome editing

Pathogenic mitochondrial DNA (mtDNA) mutations can cause a variety of human diseases. The recent development of genome-editing technologies to manipulate mtDNA, such as mitochondria-targeted DNA nucleases and base editors, offer a promising way for curing mitochondrial diseases caused by mtDNA mutat...

Full description

Bibliographic Details
Main Authors: Rui Bi, Yu Li, Min Xu, Quanzhen Zheng, Deng-Feng Zhang, Xiao Li, Guolan Ma, Bolin Xiang, Xiaojia Zhu, Hui Zhao, Xingxu Huang, Ping Zheng, Yong-Gang Yao
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:The Innovation
Subjects:
mitochondrial disease
mtDNA editing, mito-Cas9
third-generation sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2666675822001254

Internet

http://www.sciencedirect.com/science/article/pii/S2666675822001254

Similar Items