Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells

Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells

Benzoxazole derivative K313 has previously been reported to possess anti-inflammatory effects in lipopolysaccharide-induced RAW264.7 macrophages. To date, there have been no related reports on the anticancer effects of K313. In this study, we found that K313 reduced the viability of human B-cell leu...

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Bibliographic Details
Main Authors: Wenying Zhong, Xinwen Tang, Yang Liu, Chunyu Zhou, Pan Liu, Enhui Li, Peilin Zhong, Haoxue Lv, Qiang Zou, Maolin Wang
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
k313
b-cell acute lymphoblastic leukemia
b-cell burkitt’s lymphoma
cell cycle arrest
apoptosis
mitochondrial pathway
autophagy blockage
Online Access:https://www.mdpi.com/1420-3049/25/4/971

Internet

https://www.mdpi.com/1420-3049/25/4/971

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