Epigenetic reprogramming enhances the therapeutic efficacy of osteoblast‐derived extracellular vesicles to promote human bone marrow stem cell osteogenic differentiation

Epigenetic reprogramming enhances the therapeutic efficacy of osteoblast‐derived extracellular vesicles to promote human bone marrow stem cell osteogenic differentiation

Abstract Extracellular vesicles (EVs) are emerging in tissue engineering as promising acellular tools, circumventing many of the limitations associated with cell‐based therapies. Epigenetic regulation through histone deacetylase (HDAC) inhibition has been shown to increase differentiation capacity....

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Bibliographic Details
Main Authors: Kenny Man, Mathieu Y. Brunet, Maria Fernandez‐Rhodes, Soraya Williams, Liam M. Heaney, Lee A. Gethings, Angelica Federici, Owen G. Davies, David Hoey, Sophie C. Cox
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Journal of Extracellular Vesicles
Subjects:
bone
epigenetics
extracellular vesicles
histone deacetylase
microRNAs
tissue engineering
Online Access:https://doi.org/10.1002/jev2.12118

Internet

https://doi.org/10.1002/jev2.12118

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