Cellular and micro-environmental responses influencing the antitumor activity of all-trans retinoic acid in breast cancer

Cellular and micro-environmental responses influencing the antitumor activity of all-trans retinoic acid in breast cancer

Abstract All-trans retinoic acid (ATRA) is the most relevant and functionally active metabolite of Vitamin-A. From a therapeutic standpoint, ATRA is the first example of pharmacological agent exerting its anti-tumor activity via a cell differentiating action. In the clinics, ATRA is used in the trea...

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Bibliographic Details
Main Authors: Maria Azzurra Caricasulo, Adriana Zanetti, Mineko Terao, Enrico Garattini, Gabriela Paroni
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cell Communication and Signaling
Subjects:
Retinoic acid
Breast cancer
Tumor micro-environment
Differentiation therapy
Online Access:https://doi.org/10.1186/s12964-024-01492-2

Internet

https://doi.org/10.1186/s12964-024-01492-2

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