Eicosapentaenoic acid shows anti-inflammatory effect via GPR120 in 3T3-L1 adipocytes and attenuates adipose tissue inflammation in diet-induced obese mice

Eicosapentaenoic acid shows anti-inflammatory effect via GPR120 in 3T3-L1 adipocytes and attenuates adipose tissue inflammation in diet-induced obese mice

Abstract Background Saturated fatty acids have been shown to cause insulin resistance and low-grade chronic inflammation, whereas unsaturated fatty acids suppress inflammation via G-protein coupled receptor 120 (GPR120) in macrophages. However, the anti-inflammatory effects of unsaturated fatty acid...

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Bibliographic Details
Main Authors: Hodaka Yamada, Tomio Umemoto, Masafumi Kakei, Shin-ichi Momomura, Masanobu Kawakami, San-e Ishikawa, Kazuo Hara
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Nutrition & Metabolism
Subjects:
Palmitate
Adipocytes
G-protein coupled receptor 120
Eicosapentaenoic acid
Macrophage phenotype
Online Access:http://link.springer.com/article/10.1186/s12986-017-0188-0

Internet

http://link.springer.com/article/10.1186/s12986-017-0188-0

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