Identification of an Essential Region for Translocation of Clostridium difficile Toxin B

Identification of an Essential Region for Translocation of Clostridium difficile Toxin B

Clostridium difficile toxin A (TcdA) and toxin B (TcdB) are the major virulence factors involved in C. difficile-associated diarrhea and pseudomembranous colitis. TcdA and TcdB both contain at least four distinct domains: the glucosyltransferase domain, cysteine protease domain, receptor binding dom...

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Bibliographic Details
Main Authors: Shuyi Chen, Haiying Wang, Huawei Gu, Chunli Sun, Shan Li, Hanping Feng, Jufang Wang
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Toxins
Subjects:
Clostridium difficile
toxin
translocation
endocytosis
conformational change
Online Access:http://www.mdpi.com/2072-6651/8/8/241

Internet

http://www.mdpi.com/2072-6651/8/8/241

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