A Novel Variant in the <i>TP53</i> Gene Causing Li–Fraumeni Syndrome

A Novel Variant in the <i>TP53</i> Gene Causing Li–Fraumeni Syndrome

Li–Fraumeni syndrome (LFS) is an autosomal dominant hereditary cancer syndrome associated with germline pathogenic variants in the tumor protein p53 (<i>TP53</i>) gene and elevated risk of a broad range of early-onset malignancies. Patients with LFS are at risk of a second and third prim...

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Bibliographic Details
Main Authors: Dimitrios T. Papadimitriou, Constantine A. Stratakis, Antonis Kattamis, Stavros Glentis, Constantine Dimitrakakis, George P. Spyridis, Panagiotis Christopoulos, George Mastorakos, Nikolaos F. Vlahos, Nicoletta Iacovidou
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Children
Subjects:
<i>TP53</i> gene
Li–Fraumeni syndrome
adrenocortical tumor
breast cancer
cervical cancer
osteosarcoma
Online Access:https://www.mdpi.com/2227-9067/10/7/1150

Internet

https://www.mdpi.com/2227-9067/10/7/1150

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