Double Mutation at the Putative Protein Kinase C Phosphorylation Sites Thr151 Plus Thr323 in the Mouse LeukotrieneD4 Receptor Eliminates Homologous Desensitization

Double Mutation at the Putative Protein Kinase C Phosphorylation Sites Thr151 Plus Thr323 in the Mouse LeukotrieneD4 Receptor Eliminates Homologous Desensitization

Background/Aims: Signalling via CysLT1 is involved in activation of volume sensitive K+ channels and homologous desensitization of the LTD4 receptor impairs regulatory volume decrease (RVD). The aim is to illustrate the effect of mutation of putative PKC consensus phosphorylation sites in the CysLT1...

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Bibliographic Details
Main Authors: Sune T. Jørgensen, Heidi N. Eriksen, Janni Dausell, Thomas Jespersen, Ian H. Lambert, Else K. Hoffmann
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
CysLT1
LTD4
Desensitization
Xenopus laevis
Online Access:http://www.karger.com/Article/FullText/343374

Internet

http://www.karger.com/Article/FullText/343374

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