Synthesis and Characterization of New Spirooxindoles Including Triazole and Benzimidazole Pharmacophores via [3+2] Cycloaddition Reaction: An MEDT Study of the Mechanism and Selectivity

Synthesis and Characterization of New Spirooxindoles Including Triazole and Benzimidazole Pharmacophores via [3+2] Cycloaddition Reaction: An MEDT Study of the Mechanism and Selectivity

A new series of spirooxindoles based on benzimidazole, triazole, and isatin moieties were synthesized via a [3+2] cycloaddition reaction protocol in one step. The single X-ray crystal structure of the intermediate triazole-benzimidazole <b>4</b> was solved. The new chemical structures of...

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Bibliographic Details
Main Authors: Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, M. Ali, Mezna Saleh Altowyan, Mar Ríos-Gutiérrez, Sammer Yousuf, Assem Barakat
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Molecules
Subjects:
spirooxindoles
benzimidazole
triazoles
molecular electron density theory (MEDT)
Online Access:https://www.mdpi.com/1420-3049/28/19/6976

Internet

https://www.mdpi.com/1420-3049/28/19/6976

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