Curcumin derivative 1, 2-bis [(3E, 5E)-3, 5-bis [(2-chlorophenyl) methylene]-4-oxo-1-piperidyl] ethane-1, 2-dione (ST03) induces mitochondria mediated apoptosis in ovarian cancer cells and inhibits tumor progression in EAC mouse model

Curcumin derivative 1, 2-bis [(3E, 5E)-3, 5-bis [(2-chlorophenyl) methylene]-4-oxo-1-piperidyl] ethane-1, 2-dione (ST03) induces mitochondria mediated apoptosis in ovarian cancer cells and inhibits tumor progression in EAC mouse model

Curcumin is known for its anticancer properties, but its clinical application is limited due to its poor bioavailability and chemical stability. In this study we report the curcumin derivative, ST03 (1,2-bis[(3E,5E)-3,5-bis[(2-chlorophenyl)methylene]-4-oxo-1-piperidyl]ethane-1,2-dione) exhibits ∼ 14...

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Bibliographic Details
Main Authors: Jinsha Koroth, Raghunandan Mahadeva, Febina Ravindran, Tanvi R Parashar, Vinay Teja, Subhas S Karki, Bibha Choudhary
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Translational Oncology
Subjects:
Curcumin derivative
Ovarian cancer
ST03
Apoptosis
Bioavailability
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321002710

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http://www.sciencedirect.com/science/article/pii/S1936523321002710

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