Application of Pharmacokinetic and Pharmacodynamic Analysis to the Development of Liposomal Formulations for Oncology

Application of Pharmacokinetic and Pharmacodynamic Analysis to the Development of Liposomal Formulations for Oncology

Liposomal formulations of anticancer agents have been developed to prolong drug circulating lifetime, enhance anti-tumor efficacy by increasing tumor drug deposition, and reduce drug toxicity by avoiding critical normal tissues. Despite the clinical approval of numerous liposome-based chemotherapeut...

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Bibliographic Details
Main Authors: Sihem Ait-Oudhia, Donald E. Mager, Robert M. Straubinger
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Pharmaceutics
Subjects:
liposomes
nanoparticulate drug carriers
drug delivery
pharmacokinetics
pharmacodynamics
mathematical simulation
Online Access:http://www.mdpi.com/1999-4923/6/1/137

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http://www.mdpi.com/1999-4923/6/1/137

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