Soyasapogenols contained in soybeans suppress tumour progression by regulating macrophage differentiation into the protumoural phenotype

Soyasapogenols contained in soybeans suppress tumour progression by regulating macrophage differentiation into the protumoural phenotype

Tumour-associated macrophages (TAMs) polarized to the protumoural M2 phenotype promote tumour proliferation and are considered to be a therapeutic target in patients with malignant tumours. In this study, we tried to identify natural compounds that inhibit TAM polarization into the M2 phenotype. We...

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Bibliographic Details
Main Authors: Yukio Fujiwara, Daisuke Shiraishi, Makiko Yoshitomi, Tsuyoshi Ikeda, Hiroshi Mizuta, Motohiro Takeya, Yoshihiro Komohara
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Journal of Functional Foods
Subjects:
Soybean
Soyasapogenol
Macrophage
STAT3
Tumour cells
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615004879

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http://www.sciencedirect.com/science/article/pii/S1756464615004879

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