Role of the Polyol Pathway in Locomotor Recovery and Wallerian Degeneration after Spinal Cord Contusion Injury

Role of the Polyol Pathway in Locomotor Recovery and Wallerian Degeneration after Spinal Cord Contusion Injury

Spinal cord contusion injury leads to Wallerian degeneration of axonal tracts, resulting in irreversible paralysis. Contusion injury causes perfusion loss by thrombosis and vasospasm, resulting in spinal cord ischemia. In several tissues, including heart and brain, ischemia activates polyol pathway...

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Bibliographic Details
Main Authors: Richard J. Zeman, Xialing Wen, Nengtai Ouyang, Abraham M. Brown, Joseph D. Etlinger
Format: Article
Language:English
Published: Mary Ann Liebert 2021-09-01
Series:Neurotrauma Reports
Subjects:
glucose uptake
glucotoxicity
hyperglucosis
locomotor function
polyol pathway
spinal cord injury
Online Access:https://www.liebertpub.com/doi/full/10.1089/NEUR.2021.0018

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https://www.liebertpub.com/doi/full/10.1089/NEUR.2021.0018

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