Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory Cytokine IL-6 and Is Dependent on NF-κB Signaling

Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory Cytokine IL-6 and Is Dependent on NF-κB Signaling

G protein-coupled receptors (GPCRs) have emerged as key players in regulating (patho)physiological processes, including inflammation. Members of the Mas-related G protein coupled receptors (MRGPRs), a subfamily of GPCRs, are largely expressed by sensory neurons and known to modulate itch and pain. S...

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Bibliographic Details
Main Authors: Rohit Arora, Kenny M. Van Theemsche, Samuel Van Remoortel, Dirk J. Snyders, Alain J. Labro, Jean-Pierre Timmermans
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
GPCR
β-alanine
MRGPRD
constitutive receptor
Gq inhibitor
NF-kB
Online Access:https://www.mdpi.com/1422-0067/22/24/13254

Internet

https://www.mdpi.com/1422-0067/22/24/13254

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