Small GTP‐binding protein Rap1 mediates EGF and HB‐EGF signaling and modulates EGF receptor expression in HTR‐8/SVneo extravillous trophoblast cells

Small GTP‐binding protein Rap1 mediates EGF and HB‐EGF signaling and modulates EGF receptor expression in HTR‐8/SVneo extravillous trophoblast cells

Abstract Purpose Extravillous trophoblasts (EVTs) invade the endometrium to establish a fetomaternal interaction during pregnancy. Epidermal growth factor (EGF) and heparin‐binding EGF‐like growth factor (HB‐EGF) stimulate EVT invasion by binding to the EGF receptor (EGFR). We examined the role of t...

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Bibliographic Details
Main Authors: Mikihiro Yoshie, Kensuke Ohishi, Gen Ishikawa, Atsuya Tsuru, Kazuya Kusama, Mana Azumi, Kazuhiro Tamura
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Reproductive Medicine and Biology
Subjects:
EGF
extravillous trophoblast
HB‐EGF
invasion
Rap1
Online Access:https://doi.org/10.1002/rmb2.12537

Internet

https://doi.org/10.1002/rmb2.12537

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