A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery

A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery

Abstract The InterFeron Induced TransMembrane (IFITM) proteins are interferon stimulated genes that restrict many viruses, including HIV-1. SAMHD1 is another restriction factor blocking replication of HIV-1 and other viruses. Some lentiviruses evolved Vpx/Vpr proteins to degrade SAMHD1. However, thi...

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Bibliographic Details
Main Authors: Ferdinand Roesch, Molly OhAinle, Michael Emerman
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Retrovirology
Subjects:
HIV-1
SAMHD1
Vpx
Pseudotypes
Interferon
IFITM
Online Access:http://link.springer.com/article/10.1186/s12977-018-0409-2

Internet

http://link.springer.com/article/10.1186/s12977-018-0409-2

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