Granulocyte-colony stimulating factor does not prevent in vitro cisplatin-induced germ cell reduction in immature human and mouse testis

Granulocyte-colony stimulating factor does not prevent in vitro cisplatin-induced germ cell reduction in immature human and mouse testis

Abstract Background Currently there are no established fertility preservation options for pre-pubertal boys facing cancer treatment. Granulocyte-colony stimulating factor (G-CSF) treatment has been proposed to be chemoprotective against spermatogonial cell loss in an alkylating chemotherapy model of...

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Bibliographic Details
Main Authors: Gabriele Matilionyte, Grace Forsyth, Jingtao Guo, Michael P. Rimmer, Brian P. Hermann, Richard A. Anderson, Rod T. Mitchell
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Cancer
Subjects:
Human
Mouse
Testis
Cisplatin
Germ cell
Fertility preservation
Online Access:https://doi.org/10.1186/s12885-023-10702-y

Internet

https://doi.org/10.1186/s12885-023-10702-y

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