Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect

Melatonin suppresses Akt/mTOR/S6K activity, induces cell apoptosis, and synergistically inhibits cell growth with sunitinib in renal carcinoma cells via reversing Warburg effect

ABSTRACTBackground Metabolic alteration drives renal cell carcinoma (RCC) development, while the impact of melatonin (MLT), a neurohormone secreted during darkness, on RCC cell growth and underlying mechanisms remains unclear.Methods We detected concentration of metabolites through metabolomic analy...

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Bibliographic Details
Main Authors: Kai-Hua Xue, Yi-Fan Jiang, Ji-Yu Bai, Di-Ze Zhang, Yu-Hang Chen, Jian-Bin Ma, Zhi-Jing Zhu, Xinyang Wang, Peng Guo
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Redox Report
Subjects:
Melatonin
renal cell carcinoma
mitochondria
ROS
cell apoptosis
Akt/mTOR/S6K
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2023.2251234

Internet

https://www.tandfonline.com/doi/10.1080/13510002.2023.2251234

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