Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus
The mammalian intestine is an organ that can be spatially defined by two axes: longitudinal and vertical. Such anatomical structure ensures the maintenance of a relatively immuno-quiescent and proliferation-promoting crypt for intestinal stem cell differentiation while actively warding off the invad...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1057932/full |
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| author | Hongxiang Sun Hongxiang Sun Hongxiang Sun Jianmei Tan Jianmei Tan Jianmei Tan Hongqian Chen Hongqian Chen Hongqian Chen Ningbo Wu Ningbo Wu Ningbo Wu Bing Su Bing Su Bing Su Bing Su Bing Su |
| author_facet | Hongxiang Sun Hongxiang Sun Hongxiang Sun Jianmei Tan Jianmei Tan Jianmei Tan Hongqian Chen Hongqian Chen Hongqian Chen Ningbo Wu Ningbo Wu Ningbo Wu Bing Su Bing Su Bing Su Bing Su Bing Su |
| author_sort | Hongxiang Sun |
| collection | DOAJ |
| description | The mammalian intestine is an organ that can be spatially defined by two axes: longitudinal and vertical. Such anatomical structure ensures the maintenance of a relatively immuno-quiescent and proliferation-promoting crypt for intestinal stem cell differentiation while actively warding off the invading intestinal microbes at the villus tip during digestion and nutrient absorption. Such behavior is achieved by the fine coordination among intestinal epithelial cells, intestinal mesenchymal stromal cells and tissue-resident immune cells like myeloid cells and lymphocytes. Among these cell types resided in the colon, intestinal mesenchymal stromal cells are considered to be the essential link between epithelium, vasculature, neuronal system, and hematopoietic compartment. Recent advancement of single cell and spatial transcriptomics has enabled us to characterize the spatial and functional heterogeneity of intestinal mesenchymal stromal cells. These studies reveal distinctive intestinal mesenchymal stromal cells localized in different regions of the intestine with diverse functions including but not limited to providing cytokines and growth factors essential for different immune cells and epithelial cells which predict niche formation for immune function from the villus tip to the crypt bottom. In this review, we aim to provide an overall view of the heterogeneity of intestinal mesenchymal stromal cells, the spatial distribution of these cells along with their interaction with immune cells and the potential regulatory cytokine profile of these cell types. Summarization of such information may enrich our current understanding of the immuno-regulatory functions of the newly identified mesenchymal stromal cell subsets beyond their epithelial regulatory function. |
| first_indexed | 2024-04-11T23:29:23Z |
| format | Article |
| id | doaj.art-b31624184080432c8bc902bbdf1fa456 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T23:29:23Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b31624184080432c8bc902bbdf1fa4562022-12-22T03:57:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10579321057932Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villusHongxiang Sun0Hongxiang Sun1Hongxiang Sun2Jianmei Tan3Jianmei Tan4Jianmei Tan5Hongqian Chen6Hongqian Chen7Hongqian Chen8Ningbo Wu9Ningbo Wu10Ningbo Wu11Bing Su12Bing Su13Bing Su14Bing Su15Bing Su16Shanghai Institute of Immunology, Department of Immunology and Microbiology, and the Ministry of Education Key Laboratory of Cell Death and Differentiation, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Gastroenterology, Center for Immune-Related Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Jiao Tong University School of Medicine–Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Institute of Immunology, Department of Immunology and Microbiology, and the Ministry of Education Key Laboratory of Cell Death and Differentiation, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Gastroenterology, Center for Immune-Related Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Jiao Tong University School of Medicine–Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Institute of Immunology, Department of Immunology and Microbiology, and the Ministry of Education Key Laboratory of Cell Death and Differentiation, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Gastroenterology, Center for Immune-Related Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Jiao Tong University School of Medicine–Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Institute of Immunology, Department of Immunology and Microbiology, and the Ministry of Education Key Laboratory of Cell Death and Differentiation, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Gastroenterology, Center for Immune-Related Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Jiao Tong University School of Medicine–Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Institute of Immunology, Department of Immunology and Microbiology, and the Ministry of Education Key Laboratory of Cell Death and Differentiation, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Gastroenterology, Center for Immune-Related Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Jiao Tong University School of Medicine–Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaKey Laboratory of Molecular Radiation Oncology of Hunan Province, Xiangya Hospital, Central South University, Changsha, ChinaAcademy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaThe mammalian intestine is an organ that can be spatially defined by two axes: longitudinal and vertical. Such anatomical structure ensures the maintenance of a relatively immuno-quiescent and proliferation-promoting crypt for intestinal stem cell differentiation while actively warding off the invading intestinal microbes at the villus tip during digestion and nutrient absorption. Such behavior is achieved by the fine coordination among intestinal epithelial cells, intestinal mesenchymal stromal cells and tissue-resident immune cells like myeloid cells and lymphocytes. Among these cell types resided in the colon, intestinal mesenchymal stromal cells are considered to be the essential link between epithelium, vasculature, neuronal system, and hematopoietic compartment. Recent advancement of single cell and spatial transcriptomics has enabled us to characterize the spatial and functional heterogeneity of intestinal mesenchymal stromal cells. These studies reveal distinctive intestinal mesenchymal stromal cells localized in different regions of the intestine with diverse functions including but not limited to providing cytokines and growth factors essential for different immune cells and epithelial cells which predict niche formation for immune function from the villus tip to the crypt bottom. In this review, we aim to provide an overall view of the heterogeneity of intestinal mesenchymal stromal cells, the spatial distribution of these cells along with their interaction with immune cells and the potential regulatory cytokine profile of these cell types. Summarization of such information may enrich our current understanding of the immuno-regulatory functions of the newly identified mesenchymal stromal cell subsets beyond their epithelial regulatory function.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1057932/fullkintestinal mesenchymal stromal cell1crypt-villus axis2stromal-immune interaction3MRISC4telocytes5 |
| spellingShingle | Hongxiang Sun Hongxiang Sun Hongxiang Sun Jianmei Tan Jianmei Tan Jianmei Tan Hongqian Chen Hongqian Chen Hongqian Chen Ningbo Wu Ningbo Wu Ningbo Wu Bing Su Bing Su Bing Su Bing Su Bing Su Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus Frontiers in Immunology kintestinal mesenchymal stromal cell1 crypt-villus axis2 stromal-immune interaction3 MRISC4 telocytes5 |
| title | Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus |
| title_full | Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus |
| title_fullStr | Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus |
| title_full_unstemmed | Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus |
| title_short | Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus |
| title_sort | immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt villus |
| topic | kintestinal mesenchymal stromal cell1 crypt-villus axis2 stromal-immune interaction3 MRISC4 telocytes5 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1057932/full |
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