RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth

RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth

Diacylglycerol kinase β (DGKβ) is an enzyme that converts diacylglycerol to phosphatidic acid and is mainly expressed in the cerebral cortex, hippocampus and striatum. We previously reported that DGKβ induces neurite outgrowth and spinogenesis, contributing to higher brain functions, including emoti...

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Bibliographic Details
Main Authors: Takuya Kano, Ryosuke Tsumagari, Akio Nakashima, Ushio Kikkawa, Shuji Ueda, Minoru Yamanoue, Nobuyuki Takei, Yasuhito Shirai
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomolecules
Subjects:
diacylglycerol kinase
phosphatidic acid
mammalian target of rapamycin
RalA
phospholipase D (PLD)
neurite
Online Access:https://www.mdpi.com/2218-273X/11/12/1814

Internet

https://www.mdpi.com/2218-273X/11/12/1814

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