NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions
Preeclampsia (PE) is a specific syndrome of human pregnancy, being one of the main causes of maternal death. Persistent inflammation in the endothelium stimulates the secretion of several inflammatory mediators, activating different signaling patterns. One of these mechanisms is related to NLRP3 act...
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MDPI AG
2021-10-01
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| Series: | Cells |
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| author | Priscila Rezeck Nunes Sarah Viana Mattioli Valeria Cristina Sandrim |
| author_facet | Priscila Rezeck Nunes Sarah Viana Mattioli Valeria Cristina Sandrim |
| author_sort | Priscila Rezeck Nunes |
| collection | DOAJ |
| description | Preeclampsia (PE) is a specific syndrome of human pregnancy, being one of the main causes of maternal death. Persistent inflammation in the endothelium stimulates the secretion of several inflammatory mediators, activating different signaling patterns. One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis. Furthermore, reactive oxygen species (ROS), act as an intermediate to activate NLRP3, contributing to subsequent inflammatory cascades and cell damage. Moreover, increased production of ROS may elevate nitric oxide (NO) catabolism and consequently decrease NO bioavailability. NO has many roles in immune responses, including the regulation of signaling cascades. At the site of inflammation, vascular endothelium is crucial in the regulation of systemic inflammation with important implications for homeostasis. In this review, we present the important role of NLRP3 activation in exacerbating oxidative stress and endothelial dysfunction. Considering that the causes related to these processes and inflammation in PE remain a challenge for clinical practice, the use of drugs related to inhibition of the NLRP3 may be a good option for future solutions for this disease. |
| first_indexed | 2024-03-10T05:37:39Z |
| format | Article |
| id | doaj.art-b3196ddd8e02457f838ceebfdc3d444e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:37:39Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-b3196ddd8e02457f838ceebfdc3d444e2023-11-22T22:47:21ZengMDPI AGCells2073-44092021-10-011011282810.3390/cells10112828NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological InterventionsPriscila Rezeck Nunes0Sarah Viana Mattioli1Valeria Cristina Sandrim2Department of Biophysics and Pharmacology, Institute of Biosciences, Sao Paulo State University, Sao Paulo 01049-010, BrazilDepartment of Biophysics and Pharmacology, Institute of Biosciences, Sao Paulo State University, Sao Paulo 01049-010, BrazilDepartment of Biophysics and Pharmacology, Institute of Biosciences, Sao Paulo State University, Sao Paulo 01049-010, BrazilPreeclampsia (PE) is a specific syndrome of human pregnancy, being one of the main causes of maternal death. Persistent inflammation in the endothelium stimulates the secretion of several inflammatory mediators, activating different signaling patterns. One of these mechanisms is related to NLRP3 activation, initiated by high levels of danger signals such as cholesterol, urate, and glucose, producing IL-1, IL-18, and cell death by pyroptosis. Furthermore, reactive oxygen species (ROS), act as an intermediate to activate NLRP3, contributing to subsequent inflammatory cascades and cell damage. Moreover, increased production of ROS may elevate nitric oxide (NO) catabolism and consequently decrease NO bioavailability. NO has many roles in immune responses, including the regulation of signaling cascades. At the site of inflammation, vascular endothelium is crucial in the regulation of systemic inflammation with important implications for homeostasis. In this review, we present the important role of NLRP3 activation in exacerbating oxidative stress and endothelial dysfunction. Considering that the causes related to these processes and inflammation in PE remain a challenge for clinical practice, the use of drugs related to inhibition of the NLRP3 may be a good option for future solutions for this disease.https://www.mdpi.com/2073-4409/10/11/2828NLRP3preeclampsianitric oxideendothelial dysfunctionoxidative stressinflammation |
| spellingShingle | Priscila Rezeck Nunes Sarah Viana Mattioli Valeria Cristina Sandrim NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions Cells NLRP3 preeclampsia nitric oxide endothelial dysfunction oxidative stress inflammation |
| title | NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions |
| title_full | NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions |
| title_fullStr | NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions |
| title_full_unstemmed | NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions |
| title_short | NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions |
| title_sort | nlrp3 activation and its relationship to endothelial dysfunction and oxidative stress implications for preeclampsia and pharmacological interventions |
| topic | NLRP3 preeclampsia nitric oxide endothelial dysfunction oxidative stress inflammation |
| url | https://www.mdpi.com/2073-4409/10/11/2828 |
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