Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production
Four new withanolides named dmetelins A–D (compounds 1–4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spect...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-04-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/4/4548 |
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| author | Bing-You Yang Rui Guo Ting Li Yan Liu Chang-Fu Wang Zun-Peng Shu Zhi-Bin Wang Jing Zhang Yong-Gang Xia Hai Jiang Qiu-Hong Wang Hai-Xue Kuang |
| author_facet | Bing-You Yang Rui Guo Ting Li Yan Liu Chang-Fu Wang Zun-Peng Shu Zhi-Bin Wang Jing Zhang Yong-Gang Xia Hai Jiang Qiu-Hong Wang Hai-Xue Kuang |
| author_sort | Bing-You Yang |
| collection | DOAJ |
| description | Four new withanolides named dmetelins A–D (compounds 1–4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spectrometry data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells. Compounds 1, 4 and 5 showed significant inhibitory activities, and compounds 2 and 3 showed moderate inhibitory activities with IC50 values of 17.8, 11.6, 14.9, 33.3 and 28.6 μM, respectively. |
| first_indexed | 2024-12-10T14:05:47Z |
| format | Article |
| id | doaj.art-b320bc856fa546d7a4f12265eb6451e6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T14:05:47Z |
| publishDate | 2014-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-b320bc856fa546d7a4f12265eb6451e62022-12-22T01:45:40ZengMDPI AGMolecules1420-30492014-04-011944548455910.3390/molecules19044548molecules19044548Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide ProductionBing-You Yang0Rui Guo1Ting Li2Yan Liu3Chang-Fu Wang4Zun-Peng Shu5Zhi-Bin Wang6Jing Zhang7Yong-Gang Xia8Hai Jiang9Qiu-Hong Wang10Hai-Xue Kuang11Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, ChinaKey Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, ChinaFour new withanolides named dmetelins A–D (compounds 1–4), along with the known compound 7α,27-dihydroxy-1-oxo-witha-2,5,24-trienolide (5) were isolated from the leaves of Datura metel L. (Solanaceae). Their structures were elucidated on the basis of detailed analysis of 1D and 2D NMR and mass spectrometry data. All the compounds were evaluated for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells. Compounds 1, 4 and 5 showed significant inhibitory activities, and compounds 2 and 3 showed moderate inhibitory activities with IC50 values of 17.8, 11.6, 14.9, 33.3 and 28.6 μM, respectively.http://www.mdpi.com/1420-3049/19/4/4548Datura metel L.withanolidesdmetelinsNO inhibition |
| spellingShingle | Bing-You Yang Rui Guo Ting Li Yan Liu Chang-Fu Wang Zun-Peng Shu Zhi-Bin Wang Jing Zhang Yong-Gang Xia Hai Jiang Qiu-Hong Wang Hai-Xue Kuang Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production Molecules Datura metel L. withanolides dmetelins NO inhibition |
| title | Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production |
| title_full | Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production |
| title_fullStr | Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production |
| title_full_unstemmed | Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production |
| title_short | Five Withanolides from the Leaves of Datura metel L. and Their Inhibitory Effects on Nitric Oxide Production |
| title_sort | five withanolides from the leaves of datura metel l and their inhibitory effects on nitric oxide production |
| topic | Datura metel L. withanolides dmetelins NO inhibition |
| url | http://www.mdpi.com/1420-3049/19/4/4548 |
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