Untargeted metabolomics uncovers metabolic dysregulation and tissue sensitivity in ACE2 knockout mice

Untargeted metabolomics uncovers metabolic dysregulation and tissue sensitivity in ACE2 knockout mice

Angiotensin-converting enzyme 2 (ACE2) polymorphisms are associated with increased risk of type 2 diabetes mellitus (T2DM), obesity and dyslipidemia, which have been determined in various populations. Consistently, ACE2 knockout (ACE2 KO) mice display damaged energy metabolism in multiple tissues, e...

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Bibliographic Details
Main Authors: Lili Zhao, Weili Yang, Wenyi Ji, Qiuyue Pan, Jinkui Yang, Xi Cao
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
ACE2
Gene knockout
Metabolomics
Glucolipid metabolism
T2DM
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024035035

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http://www.sciencedirect.com/science/article/pii/S2405844024035035

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