A two-sample Mendelian randomization study explores metabolic profiling of different glycemic traits

Abstract We assessed the causal relation of four glycemic traits and type 2 diabetes liability with 167 metabolites using Mendelian randomization with various sensitivity analyses and a reverse Mendelian randomization analysis. We extracted instruments for fasting glucose, 2-h glucose, fasting insul...

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Bibliographic Details
Main Authors: Tommy H. T. Wong, Jacky M. Y. Mo, Mingqi Zhou, Jie V. Zhao, C. Mary Schooling, Baoting He, Shan Luo, Shiu Lun Au Yeung
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-05977-1