Pre-clinical efficacy evaluation of human umbilical cord mesenchymal stem cells for ischemic stroke

Pre-clinical efficacy evaluation of human umbilical cord mesenchymal stem cells for ischemic stroke

ObjectiveThis study explored the underlying therapeutic mechanism of human umbilical cord mesenchymal stem cells (hUCMSCs) for ischemic stroke (IS), and determined the optimal administration time windows and dose-effect relationship.MethodsThe levels of SDF-1α, IL-10, IL-6, TNF-α, BDNF, IL-1β, and V...

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Bibliographic Details
Main Authors: Danpeng Shen, Hongwei Wang, Hongyan Zhu, Cuibao Jiang, Fan Xie, Hongpeng Zhang, Qian Lv, Qi Liu, Zhiqiang Wang, Nianmin Qi, Hao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
hUCMSCs
MCAO
Ischemic stroke
Time windows
Dose-effect relationship
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1095469/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1095469/full

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