Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study

Effects of IFIH1 rs1990760 variants on systemic inflammation and outcome in critically ill COVID-19 patients in an observational translational study

Background: Variants in IFIH1, a gene coding the cytoplasmatic RNA sensor MDA5, regulate the response to viral infections. We hypothesized that IFIH1 rs199076 variants would modulate host response and outcome after severe COVID-19. Methods: Patients admitted to an intensive care unit (ICU) with conf...

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Bibliographic Details
Main Authors: Laura Amado-Rodríguez, Estefania Salgado del Riego, Juan Gomez de Ona, Inés López Alonso, Helena Gil-Pena, Cecilia López-Martínez, Paula Martín-Vicente, Antonio Lopez-Vazquez, Adrian Gonzalez Lopez, Elias Cuesta-Llavona, Raquel Rodriguez-Garcia, Jose Antonio Boga, Marta Elena alvarez-Arguelles, Juan Mayordomo-Colunga, Jose Ramon Vidal-Castineira, Irene Crespo, Margarita Fernandez, Loreto Criado, Victoria Salvadores, Francisco Jose Jimeno-Demuth, Lluis Blanch, Belen Prieto, Alejandra Fernandez-Fernandez, Carlos Lopez-Larrea, Eliecer Coto, Guillermo M Albaiceta
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
COVID
lung injury
viral infections
pharmacogenomics
corticosteroids
Online Access:https://elifesciences.org/articles/73012

Internet

https://elifesciences.org/articles/73012

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