Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle

Abstract The balance among quiescence, differentiation, and self-renewal of skeletal muscle stem cells (MuSCs) is tightly regulated by their intrinsic and extrinsic properties from the niche. How the niche controls MuSC fate remains unclear. Ribonucleotide reductase M2B (Rrm2b) modulates MuSC quiesc...

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Bibliographic Details
Main Authors: Wan-Jing Chen, I-Hsuan Lin, Chien-Wei Lee, Kiyoshi Yoshioka, Yusuke Ono, Yu-Ting Yan, Yun Yen, Yi-Fan Chen
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-022-00231-w