An Investigation of Structure-Activity Relationships of Azolylacryloyl Derivatives Yielded Potent and Long-Acting Hemoglobin Modulators for Reversing Erythrocyte Sickling

An Investigation of Structure-Activity Relationships of Azolylacryloyl Derivatives Yielded Potent and Long-Acting Hemoglobin Modulators for Reversing Erythrocyte Sickling

Aromatic aldehydes that bind to sickle hemoglobin (HbS) to increase the protein oxygen affinity and/or directly inhibit HbS polymer formation to prevent the pathological hypoxia-induced HbS polymerization and the subsequent erythrocyte sickling have for several years been studied for the treatment o...

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Bibliographic Details
Main Authors: Abdelsattar M. Omar, Osheiza Abdulmalik, Mohini S. Ghatge, Yosra A. Muhammad, Steven D. Paredes, Moustafa E. El-Araby, Martin K. Safo
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Biomolecules
Subjects:
hemoglobin
sickle cell disease
Michael addition
antisickling
oxygen equilibrium
Online Access:https://www.mdpi.com/2218-273X/10/11/1508

Internet

https://www.mdpi.com/2218-273X/10/11/1508

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