An mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine against SARS-CoV-2 variants

An mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine against SARS-CoV-2 variants

Abstract Herd immunity achieved through mass vaccination is an effective approach to prevent contagious diseases. Nonetheless, emerging SARS-CoV-2 variants with frequent mutations largely evaded humoral immunity induced by Spike-based COVID-19 vaccines. Herein, we develop a lipid nanoparticle (LNP)-...

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Bibliographic Details
Main Authors: Wanbo Tai, Shengyong Feng, Benjie Chai, Shuaiyao Lu, Guangyu Zhao, Dong Chen, Wenhai Yu, Liting Ren, Huicheng Shi, Jing Lu, Zhuming Cai, Mujia Pang, Xu Tan, Penghua Wang, Jinzhong Lin, Qiangming Sun, Xiaozhong Peng, Gong Cheng
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38751-8

Internet

https://doi.org/10.1038/s41467-023-38751-8

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