Fyn specifically Regulates the activity of red cell glucose-6-phosphate-dehydrogenase

Fyn specifically Regulates the activity of red cell glucose-6-phosphate-dehydrogenase

Fyn is a tyrosine kinase belonging to the Src family (Src-Family-Kinase, SFK), ubiquitously expressed. Previously, we report that Fyn is important in stress erythropoiesis. Here, we show that in red cells Fyn specifically stimulates G6PD activity, resulting in a 3-fold increase enzyme catalytic acti...

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Bibliographic Details
Main Authors: Matte’ Alessandro, Lupo Francesca, Tibaldi Elena, Di Paolo Maria Luisa, Federti Enrica, Andrea Carpentieri, Piero Pucci, Brunati Anna Maria, Cesaro Luca, Turrini Francesco, Gomez Manzo Saul, Soo Young Choi, Marcial Quino Jaime, Kim Dae Won, Antonella Pantaleo, Xiuli An, Iana Iatcenko, Cappellini Maria Domenica, Forni Gian Luca, De Franceschi Lucia
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Red cells
Primaquine
G6PD
Oxidation
Signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308442

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http://www.sciencedirect.com/science/article/pii/S2213231720308442

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