Risk and protection of different rare protein-coding variants of complement component C4A in age-related macular degeneration

Risk and protection of different rare protein-coding variants of complement component C4A in age-related macular degeneration

Introduction: Age-related macular degeneration (AMD) is the leading cause of central vision loss in the elderly. One-third of the genetic contribution to this disease remains unexplained.Methods: We analyzed targeted sequencing data from two independent cohorts (4,245 cases, 1,668 controls) which in...

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Bibliographic Details
Main Authors: Johanna M. Seddon, Dikha De, William Casazza, Shun-Yun Cheng, Claudio Punzo, Mark Daly, Danlei Zhou, Samantha L. Coss, John P. Atkinson, Chack-Yung Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Genetics
Subjects:
age-related macular degeneration
complement system
C4A, C4B
complement proteins
genetic associations
targeted sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1274743/full

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https://www.frontiersin.org/articles/10.3389/fgene.2023.1274743/full

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