Analyzing and Resolving Infeasibility in Flux Balance Analysis of Metabolic Networks

Analyzing and Resolving Infeasibility in Flux Balance Analysis of Metabolic Networks

Flux balance analysis (FBA) is a key method for the constraint-based analysis of metabolic networks. A technical problem may occur in FBA when known (e.g., measured) fluxes of certain reactions are integrated into an FBA scenario rendering the underlying linear program (LP) infeasible, for example,...

Full description

Bibliographic Details
Main Authors: Steffen Klamt, Axel von Kamp
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Metabolites
Subjects:
constraint-based modeling
metabolic flux analysis
mass balances
weighted least-squares
quadratic programming
<i>Escherichia coli</i>
Online Access:https://www.mdpi.com/2218-1989/12/7/585

Internet

https://www.mdpi.com/2218-1989/12/7/585

Similar Items