Identification of Tumor Mutation Burden, Microsatellite Instability, and Somatic Copy Number Alteration Derived Nine Gene Signatures to Predict Clinical Outcomes in STAD

Identification of Tumor Mutation Burden, Microsatellite Instability, and Somatic Copy Number Alteration Derived Nine Gene Signatures to Predict Clinical Outcomes in STAD

Genomic features, including tumor mutation burden (TMB), microsatellite instability (MSI), and somatic copy number alteration (SCNA), had been demonstrated to be involved with the tumor microenvironment (TME) and outcome of gastric cancer (GC). We obtained profiles of TMB, MSI, and SCNA by processin...

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Bibliographic Details
Main Authors: Chuanzhi Chen, Yi Chen, Xin Jin, Yongfeng Ding, Junjie Jiang, Haohao Wang, Yan Yang, Wu Lin, Xiangliu Chen, Yingying Huang, Lisong Teng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
gastric cancer
immunotherapy response
predictive model
copy number alteration
tumor mutation burden
microsatellite instability
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.793403/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.793403/full

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