PD-L1/PD-1 crosstalk in colorectal cancer: are we targeting the right cells?

PD-L1/PD-1 crosstalk in colorectal cancer: are we targeting the right cells?

Abstract Background The analysis of tumour-infiltrating immune cells within patients’ tumour samples in colorectal cancer (CRC) has become an independent predictor of patient survival. The tumour microenvironment and the immune checkpoints, such as PD-L1/PD-1, are relevant to the prognoses and also...

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Main Authors: Ramón Cantero-Cid, José Casas-Martin, Enrique Hernández-Jiménez, Carolina Cubillos-Zapata, Aníbal Varela-Serrano, José Avendaño-Ortiz, Marta Casarrubios, Karla Montalbán-Hernández, Ignacio Villacañas-Gil, Laura Guerra-Pastrián, Begoña Peinado, Cristóbal Marcano, Luis A Aguirre, Eduardo López-Collazo
Format: Article
Language:English
Published: BMC 2018-10-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Immune checkpoints
MMR status
PD-L1/PD-1
T-cell exhaustion
Online Access:http://link.springer.com/article/10.1186/s12885-018-4853-0

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http://link.springer.com/article/10.1186/s12885-018-4853-0

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