Reactive oxygen species enhance rAAV transduction by promoting its escape from late endosomes

Reactive oxygen species enhance rAAV transduction by promoting its escape from late endosomes

Abstract Background Recent seminal studies have revealed that endosomal reactive oxygen species (ROS) promote rather than inhibit viral infection. Some ROS generators, including shikonin and H2O2, have the potential to enhance recombinant adeno-associated virus (rAAV) transduction. However, the impa...

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Bibliographic Details
Main Authors: Xiaoping Huang, Xiao Wang, Yanxuan Ren, Pingzhang Gao, Wentao Xu, Xiaolan Xie, Yong Diao
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Virology Journal
Subjects:
Endosome
ROS
rAAV
Cathepsin B
Cathepsin L
Online Access:https://doi.org/10.1186/s12985-023-01964-w

Internet

https://doi.org/10.1186/s12985-023-01964-w

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