Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has been implicated in a broad range of cancers, and several Smo antagonists are being assessed clinically, one...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Marisa O Peluso, Veronica T Campbell, Joseph A Harari, Thomas T Tibbitts, Jennifer L Proctor, Nigel Whitebread, James M Conley, Kerry F White, Jeffery L Kutok, Margaret A Read, Karen McGovern, Kerrie L Faia
Format:	Artykuł
Język:	English
Wydane:	Public Library of Science (PLoS) 2014-01-01
Seria:	PLoS ONE
Dostęp online:	http://europepmc.org/articles/PMC3946503?pdf=render

Podobne zapisy

Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation
od: Angela M. Arensdorf, i wsp.
Wydane: (2017-06-01)

Mechanisms of Smoothened Regulation in Hedgehog Signaling
od: Jie Zhang, i wsp.
Wydane: (2021-08-01)

Pharmacological and structural studies on the hedgehog pathway receptor smoothened
od: Klindert, S
Wydane: (2023)

Dataset for phenotypic classification of genetic modifiers of smoothened and Hedgehog
od: Suresh Marada, i wsp.
Wydane: (2016-06-01)

Identification of a potent antagonist of smoothened in hedgehog signaling
od: Junwan Fan, i wsp.
Wydane: (2021-03-01)

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
od: Nachtergaele, S, i wsp.
Wydane: (2013)

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened.
od: Yongbin Chen, i wsp.
Wydane: (2011-06-01)

Structure and function of the smoothened extracellular domain in vertebrate hedgehog signaling
od: Rohatgi, Rajat, i wsp.
Wydane: (2014)

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
od: Zhao, Zhonghua, i wsp.
Wydane: (2016)

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
od: Sigrid Nachtergaele, i wsp.
Wydane: (2013-10-01)

The Role of Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis
od: Jian Yi Chai, i wsp.
Wydane: (2021-09-01)

Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.
od: Tara L Lin, i wsp.
Wydane: (2010-12-01)

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
od: Shulok Janine, i wsp.
Wydane: (2002-11-01)

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma.
od: Kirti Kandhwal Chahal, i wsp.
Wydane: (2019-01-01)

A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
od: Seongjin Seo, i wsp.
Wydane: (2011-11-01)

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates
od: Byrne, E, i wsp.
Wydane: (2017)

Molecular mechanisms of hedgehog signal transduction by the G-protein coupled receptor smoothened
od: Byrne, E
Wydane: (2017)

Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila.
od: Shuang Li, i wsp.
Wydane: (2012-01-01)

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
od: Giovanni Luchetti, i wsp.
Wydane: (2016-10-01)

Hrs promotes ubiquitination and mediates endosomal trafficking of smoothened in Drosophila hedgehog signaling.
od: Junkai Fan, i wsp.
Wydane: (2013-01-01)

Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.
od: Bomi Jung, i wsp.
Wydane: (2016-01-01)

Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.
od: Corvin D Arveseth, i wsp.
Wydane: (2021-04-01)

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors
od: Silvia Pietrobono, i wsp.
Wydane: (2018-12-01)

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling
od: Kowatsch, C, i wsp.
Wydane: (2019)

Signal transduction of the GPCR Smoothened: a key protein in Hedgehog-regulated morphogenesis and oncogenesis
od: Woolley, R
Wydane: (2021)

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.
od: Madison F Walker, i wsp.
Wydane: (2024-08-01)

FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer
od: Bingchen Han, i wsp.
Wydane: (2015-11-01)

Cilia-associated oxysterols activate Smoothened
od: Raleigh, DR, i wsp.
Wydane: (2018)

Linear and nonlinear approach for DEM smoothening
od: S. Dinesh, i wsp.
Wydane: (2006-01-01)

Linear and nonlinear approach for DEM smoothening
Wydane: (2006-01-01)

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened
od: Silvia Pietrobono, i wsp.
Wydane: (2019-06-01)

Advanced basal cell carcinoma, the hedgehog pathway, and treatment options – role of smoothened inhibitors
od: Fecher LA, i wsp.
Wydane: (2015-11-01)

Imperatorin Suppresses Aberrant Hedgehog Pathway and Overcomes Smoothened Antagonist Resistance via STAT3 Inhibition
od: Wang J, i wsp.
Wydane: (2024-11-01)

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.
od: Shuangxi Li, i wsp.
Wydane: (2016-06-01)

A Smoothening Method for the Piecewise Linear Interpolation
od: Beong In Yun
Wydane: (2015-01-01)

Structural basis for Smoothened regulation by its extracellular domains
od: Siebold, C, i wsp.
Wydane: (2016)

Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.
od: Shoujun Huang, i wsp.
Wydane: (2013-11-01)

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened
od: Marina Gonçalves Antunes, i wsp.
Wydane: (2022-09-01)

A recurrent mosaic mutation of SMO, encoding the hedgehog signal transducer Smoothened, is the major cause of Curry-Jones syndrome
od: Twigg, S, i wsp.
Wydane: (2016)

Possible solution to smoothen the torque curve of the CAMPRO engine
od: Mohiuddin, A. K. M., i wsp.
Wydane: (2011)