Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has been implicated in a broad range of cancers, and several Smo antagonists are being assessed clinically, one...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Marisa O Peluso, Veronica T Campbell, Joseph A Harari, Thomas T Tibbitts, Jennifer L Proctor, Nigel Whitebread, James M Conley, Kerry F White, Jeffery L Kutok, Margaret A Read, Karen McGovern, Kerrie L Faia
स्वरूप:	लेख
भाषा:	English
प्रकाशित:	Public Library of Science (PLoS) 2014-01-01
श्रृंखला:	PLoS ONE
ऑनलाइन पहुंच:	http://europepmc.org/articles/PMC3946503?pdf=render

समान संसाधन

Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation
द्वारा: Angela M. Arensdorf, और अन्य
प्रकाशित: (2017-06-01)

Mechanisms of Smoothened Regulation in Hedgehog Signaling
द्वारा: Jie Zhang, और अन्य
प्रकाशित: (2021-08-01)

Pharmacological and structural studies on the hedgehog pathway receptor smoothened
द्वारा: Klindert, S
प्रकाशित: (2023)

Dataset for phenotypic classification of genetic modifiers of smoothened and Hedgehog
द्वारा: Suresh Marada, और अन्य
प्रकाशित: (2016-06-01)

Identification of a potent antagonist of smoothened in hedgehog signaling
द्वारा: Junwan Fan, और अन्य
प्रकाशित: (2021-03-01)

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
द्वारा: Nachtergaele, S, और अन्य
प्रकाशित: (2013)

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened.
द्वारा: Yongbin Chen, और अन्य
प्रकाशित: (2011-06-01)

Structure and function of the smoothened extracellular domain in vertebrate hedgehog signaling
द्वारा: Rohatgi, Rajat, और अन्य
प्रकाशित: (2014)

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
द्वारा: Zhao, Zhonghua, और अन्य
प्रकाशित: (2016)

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
द्वारा: Sigrid Nachtergaele, और अन्य
प्रकाशित: (2013-10-01)

The Role of Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis
द्वारा: Jian Yi Chai, और अन्य
प्रकाशित: (2021-09-01)

Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.
द्वारा: Tara L Lin, और अन्य
प्रकाशित: (2010-12-01)

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
द्वारा: Shulok Janine, और अन्य
प्रकाशित: (2002-11-01)

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma.
द्वारा: Kirti Kandhwal Chahal, और अन्य
प्रकाशित: (2019-01-01)

A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
द्वारा: Seongjin Seo, और अन्य
प्रकाशित: (2011-11-01)

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates
द्वारा: Byrne, E, और अन्य
प्रकाशित: (2017)

Molecular mechanisms of hedgehog signal transduction by the G-protein coupled receptor smoothened
द्वारा: Byrne, E
प्रकाशित: (2017)

Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila.
द्वारा: Shuang Li, और अन्य
प्रकाशित: (2012-01-01)

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
द्वारा: Giovanni Luchetti, और अन्य
प्रकाशित: (2016-10-01)

Hrs promotes ubiquitination and mediates endosomal trafficking of smoothened in Drosophila hedgehog signaling.
द्वारा: Junkai Fan, और अन्य
प्रकाशित: (2013-01-01)

Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.
द्वारा: Bomi Jung, और अन्य
प्रकाशित: (2016-01-01)

Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.
द्वारा: Corvin D Arveseth, और अन्य
प्रकाशित: (2021-04-01)

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors
द्वारा: Silvia Pietrobono, और अन्य
प्रकाशित: (2018-12-01)

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling
द्वारा: Kowatsch, C, और अन्य
प्रकाशित: (2019)

Signal transduction of the GPCR Smoothened: a key protein in Hedgehog-regulated morphogenesis and oncogenesis
द्वारा: Woolley, R
प्रकाशित: (2021)

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.
द्वारा: Madison F Walker, और अन्य
प्रकाशित: (2024-08-01)

FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer
द्वारा: Bingchen Han, और अन्य
प्रकाशित: (2015-11-01)

Cilia-associated oxysterols activate Smoothened
द्वारा: Raleigh, DR, और अन्य
प्रकाशित: (2018)

Linear and nonlinear approach for DEM smoothening
द्वारा: S. Dinesh, और अन्य
प्रकाशित: (2006-01-01)

Linear and nonlinear approach for DEM smoothening
प्रकाशित: (2006-01-01)

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened
द्वारा: Silvia Pietrobono, और अन्य
प्रकाशित: (2019-06-01)

Advanced basal cell carcinoma, the hedgehog pathway, and treatment options – role of smoothened inhibitors
द्वारा: Fecher LA, और अन्य
प्रकाशित: (2015-11-01)

Imperatorin Suppresses Aberrant Hedgehog Pathway and Overcomes Smoothened Antagonist Resistance via STAT3 Inhibition
द्वारा: Wang J, और अन्य
प्रकाशित: (2024-11-01)

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.
द्वारा: Shuangxi Li, और अन्य
प्रकाशित: (2016-06-01)

A Smoothening Method for the Piecewise Linear Interpolation
द्वारा: Beong In Yun
प्रकाशित: (2015-01-01)

Structural basis for Smoothened regulation by its extracellular domains
द्वारा: Siebold, C, और अन्य
प्रकाशित: (2016)

Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.
द्वारा: Shoujun Huang, और अन्य
प्रकाशित: (2013-11-01)

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened
द्वारा: Marina Gonçalves Antunes, और अन्य
प्रकाशित: (2022-09-01)

A recurrent mosaic mutation of SMO, encoding the hedgehog signal transducer Smoothened, is the major cause of Curry-Jones syndrome
द्वारा: Twigg, S, और अन्य
प्रकाशित: (2016)

Possible solution to smoothen the torque curve of the CAMPRO engine
द्वारा: Mohiuddin, A. K. M., और अन्य
प्रकाशित: (2011)