Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.

A requisite step for canonical Hedgehog (Hh) pathway activation by Sonic Hedgehog (Shh) ligand is accumulation of Smoothened (Smo) to the primary cilium (PC). Activation of the Hh pathway has been implicated in a broad range of cancers, and several Smo antagonists are being assessed clinically, one...

Descripció completa

Dades bibliogràfiques
Autors principals:	Marisa O Peluso, Veronica T Campbell, Joseph A Harari, Thomas T Tibbitts, Jennifer L Proctor, Nigel Whitebread, James M Conley, Kerry F White, Jeffery L Kutok, Margaret A Read, Karen McGovern, Kerrie L Faia
Format:	Article
Idioma:	English
Publicat:	Public Library of Science (PLoS) 2014-01-01
Col·lecció:	PLoS ONE
Accés en línia:	http://europepmc.org/articles/PMC3946503?pdf=render

Ítems similars

Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation
per: Angela M. Arensdorf, et al.
Publicat: (2017-06-01)

Mechanisms of Smoothened Regulation in Hedgehog Signaling
per: Jie Zhang, et al.
Publicat: (2021-08-01)

Pharmacological and structural studies on the hedgehog pathway receptor smoothened
per: Klindert, S
Publicat: (2023)

Dataset for phenotypic classification of genetic modifiers of smoothened and Hedgehog
per: Suresh Marada, et al.
Publicat: (2016-06-01)

Identification of a potent antagonist of smoothened in hedgehog signaling
per: Junwan Fan, et al.
Publicat: (2021-03-01)

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
per: Nachtergaele, S, et al.
Publicat: (2013)

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened.
per: Yongbin Chen, et al.
Publicat: (2011-06-01)

Structure and function of the smoothened extracellular domain in vertebrate hedgehog signaling
per: Rohatgi, Rajat, et al.
Publicat: (2014)

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
per: Zhao, Zhonghua, et al.
Publicat: (2016)

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
per: Sigrid Nachtergaele, et al.
Publicat: (2013-10-01)

The Role of Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis
per: Jian Yi Chai, et al.
Publicat: (2021-09-01)

Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.
per: Tara L Lin, et al.
Publicat: (2010-12-01)

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
per: Shulok Janine, et al.
Publicat: (2002-11-01)

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma.
per: Kirti Kandhwal Chahal, et al.
Publicat: (2019-01-01)

A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
per: Seongjin Seo, et al.
Publicat: (2011-11-01)

Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates
per: Byrne, E, et al.
Publicat: (2017)

Molecular mechanisms of hedgehog signal transduction by the G-protein coupled receptor smoothened
per: Byrne, E
Publicat: (2017)

Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila.
per: Shuang Li, et al.
Publicat: (2012-01-01)

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
per: Giovanni Luchetti, et al.
Publicat: (2016-10-01)

Hrs promotes ubiquitination and mediates endosomal trafficking of smoothened in Drosophila hedgehog signaling.
per: Junkai Fan, et al.
Publicat: (2013-01-01)

Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.
per: Bomi Jung, et al.
Publicat: (2016-01-01)

Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.
per: Corvin D Arveseth, et al.
Publicat: (2021-04-01)

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors
per: Silvia Pietrobono, et al.
Publicat: (2018-12-01)

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling
per: Kowatsch, C, et al.
Publicat: (2019)

Signal transduction of the GPCR Smoothened: a key protein in Hedgehog-regulated morphogenesis and oncogenesis
per: Woolley, R
Publicat: (2021)

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.
per: Madison F Walker, et al.
Publicat: (2024-08-01)

FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer
per: Bingchen Han, et al.
Publicat: (2015-11-01)

Cilia-associated oxysterols activate Smoothened
per: Raleigh, DR, et al.
Publicat: (2018)

Linear and nonlinear approach for DEM smoothening
per: S. Dinesh, et al.
Publicat: (2006-01-01)

Linear and nonlinear approach for DEM smoothening
Publicat: (2006-01-01)

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened
per: Silvia Pietrobono, et al.
Publicat: (2019-06-01)

Advanced basal cell carcinoma, the hedgehog pathway, and treatment options – role of smoothened inhibitors
per: Fecher LA, et al.
Publicat: (2015-11-01)

Imperatorin Suppresses Aberrant Hedgehog Pathway and Overcomes Smoothened Antagonist Resistance via STAT3 Inhibition
per: Wang J, et al.
Publicat: (2024-11-01)

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.
per: Shuangxi Li, et al.
Publicat: (2016-06-01)

A Smoothening Method for the Piecewise Linear Interpolation
per: Beong In Yun
Publicat: (2015-01-01)

Structural basis for Smoothened regulation by its extracellular domains
per: Siebold, C, et al.
Publicat: (2016)

Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.
per: Shoujun Huang, et al.
Publicat: (2013-11-01)

High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened
per: Marina Gonçalves Antunes, et al.
Publicat: (2022-09-01)

A recurrent mosaic mutation of SMO, encoding the hedgehog signal transducer Smoothened, is the major cause of Curry-Jones syndrome
per: Twigg, S, et al.
Publicat: (2016)

Possible solution to smoothen the torque curve of the CAMPRO engine
per: Mohiuddin, A. K. M., et al.
Publicat: (2011)