Synonymous codon usage regulates translation initiation

Summary: Nonoptimal synonymous codons repress gene expression, but the underlying mechanisms are poorly understood. We and others have previously shown that nonoptimal codons slow translation elongation speeds and thereby trigger messenger RNA (mRNA) degradation. Nevertheless, transcript levels are...

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Bibliographic Details
Main Authors: Chloe L. Barrington, Gabriel Galindo, Amanda L. Koch, Emma R. Horton, Evan J. Morrison, Samantha Tisa, Timothy J. Stasevich, Olivia S. Rissland
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723014250