Minoxidil weakens newly synthesized collagen in fibrotic synoviocytes from osteoarthritis patients

Minoxidil weakens newly synthesized collagen in fibrotic synoviocytes from osteoarthritis patients

Abstract Purpose Synovial fibrosis (SFb) formation and turnover attributable to knee osteoarthritis (KOA) can impart painful stiffness and persist following arthroplasty. To supplement joint conditioning aimed at maximizing peri‐operative function, we evaluated the antifibrotic effect of Minoxidil (...

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Bibliographic Details
Main Authors: Stefan Sarkovich, Peter P. Issa, Andrew Longanecker, Davis Martin, Kaitlyn Redondo, Patrick McTernan, Jennifer Simkin, Luis Marrero
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Journal of Experimental Orthopaedics
Subjects:
Osteoarthritis
Synovium
Synovial fibroblasts
Fibrosis
Collagen type I
Pyridinoline
Online Access:https://doi.org/10.1186/s40634-023-00650-8

Internet

https://doi.org/10.1186/s40634-023-00650-8

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