XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells

XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells

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Summary: Emerging data suggest that induction of viral mimicry responses through activation of double-stranded RNA (dsRNA) sensors in cancer cells is a promising therapeutic strategy. One approach to induce viral mimicry is to target molecular regulators of dsRNA sensing pathways. Here, we show that...

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Bibliographic Details
Main Authors: Tao Zou, Meng Zhou, Akansha Gupta, Patrick Zhuang, Alyssa R. Fishbein, Hope Y. Wei, Diego Capcha-Rodriguez, Zhouwei Zhang, Andrew D. Cherniack, Matthew Meyerson
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723016121

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http://www.sciencedirect.com/science/article/pii/S2211124723016121

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