Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice

Cognitive decline, Aβ pathology, and blood–brain barrier function in aged 5xFAD mice

Abstract Background Patients with Alzheimer's disease (AD) develop blood–brain barrier dysfunction to varying degrees. How aging impacts Aβ pathology, blood–brain barrier function, and cognitive decline in AD remains largely unknown. In this study, we used 5xFAD mice to investigate changes in A...

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Bibliographic Details
Main Authors: Geetika Nehra, Sasivimon Promsan, Ruedeemars Yubolphan, Wijitra Chumboatong, Pornpun Vivithanaporn, Bryan J. Maloney, Anusorn Lungkaphin, Bjoern Bauer, Anika M. S. Hartz
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Fluids and Barriers of the CNS
Subjects:
5xFAD
Blood–Brain Barrier
Aβ
Pde6b rd1
Online Access:https://doi.org/10.1186/s12987-024-00531-x

Internet

https://doi.org/10.1186/s12987-024-00531-x

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