Liver saturated fat content associates with hepatic DNA methylation in obese individuals

Liver saturated fat content associates with hepatic DNA methylation in obese individuals

Abstract Background Accumulation of saturated fatty acids (SFAs) in the liver is known to induce hepatic steatosis and inflammation causing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Although SFAs have been shown to affect the epigenome in whole blood, pancre...

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Bibliographic Details
Main Authors: Ratika Sehgal, Alexander Perfilyev, Ville Männistö, Jyrki Ågren, Emma Nilsson, Pirjo Käkelä, Charlotte Ling, Vanessa D. de Mello, Jussi Pihlajamäki
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Clinical Epigenetics
Subjects:
Saturated fatty acids
NAFLD
DNA methylation
Obesity
Fasting plasma glucose
Epigenetics
Online Access:https://doi.org/10.1186/s13148-023-01431-x

Internet

https://doi.org/10.1186/s13148-023-01431-x

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