Peripheral CCL2 induces inflammatory pain via regulation of Ih currents in small diameter DRG neurons

Peripheral CCL2 induces inflammatory pain via regulation of Ih currents in small diameter DRG neurons

The C-C motif chemokine ligand 2 (CCL2) has been implicated in chronic pain, but its exact mechanism of peripheral sensitization is unknown. In this study, we aimed to clarify the mechanism of CCL2 regulation of ion channels. Our behavioral experiments revealed that ZD7288, a blocker of Ih current,...

Full description

Bibliographic Details
Main Authors: Lamei Li, Yuanying Liu, Wenchao Hu, Jing Yang, Suibin Ma, Zhicheng Tian, Zixuan Cao, Kunqing Pan, Ming Jiang, Xia Liu, Shengxi Wu, Ceng Luo, Rou-Gang Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
the C-C motif chemokine ligand 2 (CCL2)
the C-C motif chemokine receptor 2 (CCR2)
dorsal root ganglion (DRG)
hyperpolarization-activated current (IH)
nociceptor
Pain
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1144614/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1144614/full

Similar Items