Metformin use and the risk of total knee replacement among diabetic patients: a propensity-score-matched retrospective cohort study

Abstract Metformin has been shown to modulate meta-inflammation, an important pathogenesis in knee osteoarthritis (OA). The study aimed to test the association between regular metformin use with total knee replacement (TKR) in patients with diabetes. This is a retrospective study with electronic rec...

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Bibliographic Details
Main Authors: Francisco T. T. Lai, Benjamin H. K. Yip, David J. Hunter, David P. Rabago, Christian D. Mallen, Eng-Kiong Yeoh, Samuel Y. S. Wong, Regina WS. Sit
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15871-7