Increasing NPYergic transmission in the hippocampus rescues aging-related deficits of long-term potentiation in the mouse dentate gyrus

Increasing NPYergic transmission in the hippocampus rescues aging-related deficits of long-term potentiation in the mouse dentate gyrus

Loss of neuropeptide Y (NPY)-expressing interneurons in the hippocampus and decaying cholinergic neuromodulation are thought to contribute to impaired cognitive function during aging. However, the interaction of these two neuromodulatory systems in maintaining hippocampal synaptic plasticity during...

Full description

Bibliographic Details
Main Authors: Katharina Klinger, Miguel del Ángel, Gürsel Çalışkan, Oliver Stork
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
healthy aging
dorsal dentate gyrus
long-term potentiation
neuropeptide-Y
cholinergic system
NPYergic system
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1283581/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1283581/full

Similar Items