CircSMAD4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving miR-377-3p-mediated BMP7 inhibition

CircSMAD4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving miR-377-3p-mediated BMP7 inhibition

Abstract Background Diabetic nephropathy (DN) is a common complication of diabetes mellitus. Accumulating studies suggest that the deregulation of circular RNA (circRNA) is involved in DN pathogenesis. This study aimed to investigate the role of circSMAD4 in DN models. Methods Mice were treated with...

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Bibliographic Details
Main Authors: Rina Wu, Zheli Niu, Guangwei Ren, Lin Ruan, Lijun Sun
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Diabetology & Metabolic Syndrome
Subjects:
circSMAD4
miR-377-3p
BMP7
Diabetic nephropathy
Online Access:https://doi.org/10.1186/s13098-021-00753-1

Internet

https://doi.org/10.1186/s13098-021-00753-1

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