Secretory phosphoprotein 1 secreted by fibroblast-like synoviocytes promotes osteoclasts formation via PI3K/AKT signaling in collagen-induced arthritis

Secretory phosphoprotein 1 secreted by fibroblast-like synoviocytes promotes osteoclasts formation via PI3K/AKT signaling in collagen-induced arthritis

Synovial tissue hyperplasia is a major cause of bone damage in rheumatoid arthritis (RA). Over-proliferation and secretion of cytokines of fibroblast-like synoviocytes (FLSs) are key contributors to bone damage in the joint microenvironment. Therefore, inhibition of FLSs-mediated bone damage is of g...

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Bibliographic Details
Main Authors: Xiaoyu Cai, Yan Zheng, Fujia Ren, Shiwei Zhang, Linwen Wu, Yao Yao
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
SPP1
Rheumatoid arthritis
FLSs
Osteoclasts
Sequencing
Bone damage
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222010769

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http://www.sciencedirect.com/science/article/pii/S0753332222010769

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